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(FƒÉ¨Ñ^;ÎÖ’   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  $Õ<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="0" name="KanR" directionality="2" translationMW="30964.00" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5935-6750" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSHIQRETSCSRPRLNSNMDADLYGYKWARDNVGQSGATIYRLYGKPDAPELFLKHGKGSVANVVTDEMVRLNWLTEFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF*"/></Q></Feature><Feature recentID="1" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4755-4761" color="#ffffff" type="standard"/><Segment range="4762-4780" color="#ffffff" type="standard"/><Segment name="-35" range="4781-4786" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4801-4822" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4731-4747" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5176-5764" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="pSa ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7041-407" color="#ffff00" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;origin of replication from bacterial plasmid pSa&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2275-2293" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="T3 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4668-4686" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T3 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="luciferase" directionality="1" translationMW="60645.64" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2718-4370" color="#ffcc00" type="standard" translated="1"/><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc+&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enhanced&amp;nbsp;&lt;i&gt;luc+&lt;/i&gt; version of the luciferase gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVDITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMGISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKIAV*"/></Q></Feature><Feature recentID="9" name="Rluc" directionality="2" translationMW="36023.08" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="854-1789" color="#00ffff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;luciferase from the anthozoan coelenterate &lt;i&gt;Renilla reniformis&lt;/i&gt; (sea pansy)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTSKVYDPEQRKRMITGPQWWARCKQMNVLDSFINYYDSEKHAENAVIFLHGNAASSYLWRHVVPHIEPVARCIIPDLIGMGKSGKSGNGSYRLLDHYKYLTAWFELLNLPKKIIFVGHDWGACLAFHYSYEHQDKIKAIVHAESVVDVIESWDEWPDIEEDIALIKSEEGEKMVLENNFFVETMLPSKIMRKLEPEEFAAYLEPFKEKGEVRRPTLSWPREIPLVKGGKPDVVQIVRNYNAYLRASDDLPKMFIESDPGFFSNAIVEGAKKFPNTEFVKVKGLHFSQEDAPDEMGKYIKSFVERVLKNEQ*"/></Q></Feature><Feature recentID="10" name="CaMV 35S promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2368-2711" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;strong constitutive promoter from cauliflower mosaic virus&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="NOS promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1823-2002" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;nopaline synthase promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="NOS terminator" type="terminator" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="587-839" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;nopaline synthase terminator and poly(A) signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="LB T-DNA repeat" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="542-564" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;left border repeat from nopaline C58 T-DNA (truncated)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="RB T-DNA repeat" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5061-5085" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;right border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2249-2265" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4707-4723" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  =<?xml version="1.0"?><Primers nextValidID="11"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="35S promoter" sequence="CTATCCTTCGCAAGACCCTTC" description="CaMV 35S promoter, forward primer"><BindingSite location="2655-2675" boundStrand="0" annealedBases="CTATCCTTCGCAAGACCCTTC" meltingTemperature="56"><Component hybridizedRange="2655-2675" bases="CTATCCTTCGCAAGACCCTTC"/></BindingSite><BindingSite simplified="1" location="2655-2675" boundStrand="0" annealedBases="CTATCCTTCGCAAGACCCTTC" meltingTemperature="56"><Component hybridizedRange="2655-2675" bases="CTATCCTTCGCAAGACCCTTC"/></BindingSite></Primer><Primer recentID="1" name="Kan-R" sequence="ATCGCGAGCCCATTTATACC" description="Kanamycin resistance gene, reverse primer"><BindingSite location="6657-6676" boundStrand="0" annealedBases="ATCGCGAGCCCATTTATACC" meltingTemperature="57"><Component hybridizedRange="6657-6676" bases="ATCGCGAGCCCATTTATACC"/></BindingSite><BindingSite simplified="1" location="6657-6676" boundStrand="0" annealedBases="ATCGCGAGCCCATTTATACC" meltingTemperature="57"><Component hybridizedRange="6657-6676" bases="ATCGCGAGCCCATTTATACC"/></BindingSite></Primer><Primer recentID="2" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="4938-4955" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="4938-4955" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="4938-4955" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="4938-4955" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite></Primer><Primer recentID="3" name="LucNrev" sequence="CCTTATGCAGTTGCTCTCC" description="Firefly luciferase, reverse primer"><BindingSite location="2783-2801" boundStrand="1" annealedBases="CCTTATGCAGTTGCTCTCC" meltingTemperature="55"><Component hybridizedRange="2783-2801" bases="CCTTATGCAGTTGCTCTCC"/></BindingSite><BindingSite simplified="1" location="2783-2801" boundStrand="1" annealedBases="CCTTATGCAGTTGCTCTCC" meltingTemperature="55"><Component hybridizedRange="2783-2801" bases="CCTTATGCAGTTGCTCTCC"/></BindingSite></Primer><Primer recentID="4" name="M13 Forward" sequence="TGTAAAACGACGGCCAGT" description="In lacZ gene. Also called M13-F20 or M13 (-21) Forward"><BindingSite location="2247-2264" boundStrand="0" annealedBases="TGTAAAACGACGGCCAGT" meltingTemperature="57"><Component hybridizedRange="2247-2264" bases="TGTAAAACGACGGCCAGT"/></BindingSite><BindingSite simplified="1" location="2247-2264" boundStrand="0" annealedBases="TGTAAAACGACGGCCAGT" meltingTemperature="57"><Component hybridizedRange="2247-2264" bases="TGTAAAACGACGGCCAGT"/></BindingSite></Primer><Primer recentID="5" name="M13 Reverse" sequence="CAGGAAACAGCTATGAC" description="In lacZ gene. Also called M13-rev"><BindingSite location="4706-4722" boundStrand="1" annealedBases="CAGGAAACAGCTATGAC" meltingTemperature="49"><Component hybridizedRange="4706-4722" bases="CAGGAAACAGCTATGAC"/></BindingSite><BindingSite simplified="1" location="4706-4722" boundStrand="1" annealedBases="CAGGAAACAGCTATGAC" meltingTemperature="49"><Component hybridizedRange="4706-4722" bases="CAGGAAACAGCTATGAC"/></BindingSite></Primer><Primer recentID="6" name="M13/pUC Forward" sequence="CCCAGTCACGACGTTGTAAAACG" description="In lacZ gene"><BindingSite location="2233-2255" boundStrand="0" annealedBases="CCCAGTCACGACGTTGTAAAACG" meltingTemperature="61"><Component hybridizedRange="2233-2255" bases="CCCAGTCACGACGTTGTAAAACG"/></BindingSite><BindingSite simplified="1" location="2233-2255" boundStrand="0" annealedBases="CCCAGTCACGACGTTGTAAAACG" meltingTemperature="61"><Component hybridizedRange="2233-2255" bases="CCCAGTCACGACGTTGTAAAACG"/></BindingSite></Primer><Primer recentID="7" name="M13/pUC Reverse" sequence="AGCGGATAACAATTTCACACAGG" description="In lacZ gene"><BindingSite location="4719-4741" boundStrand="1" annealedBases="AGCGGATAACAATTTCACACAGG" meltingTemperature="58"><Component hybridizedRange="4719-4741" bases="AGCGGATAACAATTTCACACAGG"/></BindingSite><BindingSite simplified="1" location="4719-4741" boundStrand="1" annealedBases="AGCGGATAACAATTTCACACAGG" meltingTemperature="58"><Component hybridizedRange="4719-4741" bases="AGCGGATAACAATTTCACACAGG"/></BindingSite></Primer><Primer recentID="8" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="5255-5274" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="5255-5274" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="5255-5274" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="5255-5274" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer><Primer recentID="9" name="pENTR-R" sequence="ATGGCTCATAACACCCCTTG" description="pENTR vectors, reverse primer"><BindingSite location="6741-6760" boundStrand="0" annealedBases="ATGGCTCATAACACCCCTTG" meltingTemperature="57"><Component hybridizedRange="6741-6760" bases="ATGGCTCATAACACCCCTTG"/></BindingSite><BindingSite simplified="1" location="6741-6760" boundStrand="0" annealedBases="ATGGCTCATAACACCCCTTG" meltingTemperature="57"><Component hybridizedRange="6741-6760" bases="ATGGCTCATAACACCCCTTG"/></BindingSite></Primer><Primer recentID="10" name="T7" sequence="TAATACGACTCACTATAGGG" description="T7 promoter, forward primer"><BindingSite location="2274-2293" boundStrand="0" annealedBases="TAATACGACTCACTATAGGG" meltingTemperature="50"><Component hybridizedRange="2274-2293" bases="TAATACGACTCACTATAGGG"/></BindingSite><BindingSite simplified="1" location="2274-2293" boundStrand="0" annealedBases="TAATACGACTCACTATAGGG" meltingTemperature="50"><Component hybridizedRange="2274-2293" bases="TAATACGACTCACTATAGGG"/></BindingSite></Primer></Primers>
  Ä<Notes>
<UUID>d41f4ab0-86fa-422b-82f0-fb3843a6f0b2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pGreen_dualluc_3'UTR_sensor</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>Dual-luciferase reporter for microRNA targeting in plants.</Description>
<Created UTC="21:12:48">2021.5.12</Created>
<LastModified UTC="21:12:48">2021.5.12</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference pubMedID="24510721" journal="Plant Cell. 2014 Feb;26(2):741-53. doi: 10.1105/tpc.113.120972. Epub 2014 Feb 7." date="2014-02" issue="2" authors="Liu Q, Wang F, Axtell MJ" volume="26" title="Analysis of complementarity requirements for plant MicroRNA targeting using a Nicotiana benthamiana quantitative transient assay." doi="10.1105/tpc.113.120972" journalName="Plant Cell" pages="741-53" type="Journal Article"/>
</References>
</Notes>
  Y     –         
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   )<?xml version="1.0"?><CustomEnzymeSets/>
